Progressive supranuclear palsy

• aliases:: Steele-Richardson-Olszewski syndrome
• a 'Parkinson Plus' syndrome

Features

• postural instability and falls
  • patients tend to have a stiff, broad-based gait
• impairment of vertical gaze (down gaze worse than up gaze - patients may complain of difficultly reading or descending stairs)
• parkinsonism
  • bradykinesia is prominent
• cognitive impairment
  • primarily frontal lobe dysfunction

Management

• poor response to L-dopa