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IHC of Cirrhosis

Ideal Core Needle Liver Biopsy

  • Length of Biopsy Specimen: For accurate and reliable grading and staging of chronic viral hepatitis, a biopsy specimen should be:
    • At least 2 cm in length
    • Contain at least 11 complete portal tracts
  • Micronodular Cirrhosis: Characterized by:
    • ≤3 mm nodules

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Histology - Stains for Liver Disorders

  • Hemochromatosis
    • Stain: Prussian blue stain
    • Purpose: Detects iron deposition in tissues.
  • Wilson's Disease
    • Stain: Rhodanine stain (Red)
    • Purpose: Detects copper accumulation in the liver.
  • Alpha-1 Antitrypsin Deficiency
    • Characteristic: Diastase-resistant hyaline inclusions
    • Purpose: Identifies abnormal alpha-1 antitrypsin protein in liver cells.