Pancreatic Cancer & Management

Risk Factors :

Genetic Syndromes

Untitled

💡 Which of the following is not true regarding genetic disorders with risk factor for PDAC • A-Peutz Jeghers has the highest risk of developing PDAC • B-40% of patients with hereditary pancreatitis develop PAC • C-FAP has lowest risk of developing PDAC **• D-Familial pancreatic cancer has autosomal dominant inheritance** Ans : Option D is false because familial pancreatic cancer has increased risk but doesnot follow any inheritence pattern ; Most Common mutations are BRCA 2 > PALB 2. studies suggested 9 fold increased risk of pancreatic cancer in first degree relatives of familial pancreatic cancer compared to 2 fold in sporadic cases. Option C controversial because Sabiston says FAP is lowest risk but Blumgart says LYNCH Sx has Lowest risk. Familial Pancreatic Cancer syndrome is different from Familial Pancreatitis ( Hereditary Pancreatitis)

Molecular Pathogenesis

Untitled

Imaging of PDAC:

Pancreatic Protocol CT • Triphasic • 3mm slice • Non contrast, ,Pancreatic phase, Portal venous phase • Pancreatic phase : 35-40 second (late arterial) • PDAC- hypodense, NET- hyperdense(arterial enhancing) • Portal venous phase :70 second delay

Untitled