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Presbycusis

BASICS

  • Definition: Age-related hearing loss (HL); gradual, progressive, bilateral, often high-frequency sensorineural HL with tinnitus.
  • Presentation: Difficulty hearing in noisy environments; reduced clarity, especially for speech; “clarity” of sounds affected.
  • Types:
  • Central: CNS degeneration affecting perception/speech.
  • Peripheral: Bilateral sensorineural HL (SNHL), symmetric.
  • No cure; management is risk factor mitigation and auditory amplification (hearing aids).

EPIDEMIOLOGY

  • Prevalence: Increases with age.
  • 60–69 years: 27%
  • 70–79 years: 55%
  • 80 years: 81%

  • Male > Female

ETIOLOGY AND PATHOPHYSIOLOGY

  • Cochlear hair cells—critical for hearing—are lost due to noise, disease, ototoxins, and aging.
  • Causes: Accumulated noise exposure, systemic disease, ototoxic drugs, genetics, oxidative damage.
  • Genetic Links: GSTM1, GSTT1, NAT2*6A, GRM7, GRHL2, DFNA5, MYO6, KCNQ4; mitochondrial mutations.
  • Mechanism: Hair cells don’t regenerate—damage = permanent HL.

RISK FACTORS

  • Advancing age
  • Noise exposure (military, industrial, leisure)
  • Ototoxic drugs (aminoglycosides, cisplatin, salicylates, NSAIDs, diuretics)
  • Smoking, alcohol
  • Low socioeconomic status
  • Family history, head trauma, otologic diseases
  • Cardiovascular disease, diabetes, autoimmune/metabolic/endocrine disorders

PREVENTION

  • Avoid hazardous noise exposure; use hearing protection.
  • Screening: No USPSTF recommendation for routine adult screening. Tools: Hearing Handicap Inventory for the Elderly.
  • RCT evidence: Screening + intervention increases hearing aid use vs. controls.

COMMONLY ASSOCIATED CONDITIONS

  • Accelerated cognitive decline, dementia
  • Depression, social isolation, anxiety

DIAGNOSIS

History

  • Progressive, symmetric, high-frequency HL
  • Speech difficulties in noisy environments
  • Difficulty localizing sound; family/caregiver often notice first
  • Tinnitus, but no otalgia, otorrhea, or vertigo
  • If unilateral HL: consider alternate diagnosis

Physical Exam

  • Whispered voice test
  • Otoscopy: rule out infection, tumor, cerumen impaction, TM perforation
  • Rinne/Weber: help distinguish SNHL vs. conductive HL (not for general screening)

Differential Diagnosis

  • Cerumen impaction, foreign body, chronic otitis, cholesteatoma, otosclerosis, perilymph fistula, Ménière disease, acoustic neuroma (unilateral), autoimmune HL, trauma, vascular anomaly

Diagnostic Tests

  • Audiometry: Symmetric high-frequency SNHL; descending slope; >2kHz affected first
  • Imaging: Only if asymmetric HL (MRI for acoustic neuroma)
  • Labs/other: Not routinely needed

TREATMENT

General

  • No cure. Focus on risk mitigation and amplification.

Hearing Aids (HAs)

  • Mainstay: OTC options for mild/moderate HL.
  • Types: Analog (basic amplification), digital (programmable, background noise reduction, better adaptation).
  • Average gain: ~16 dB.
  • Loudness recruitment: Hypersensitivity to loud sounds

Hearing-Assistive Technologies (HATs)

  • Alone or with HAs
  • FM/infrared systems, induction loops, TDD, TV/telephone amplifiers, alerting devices

Aural Rehabilitation

  • Patient education, training in device use, speech perception, coping strategies

Cochlear Implants (CIs)

  • Indication: Poor aided hearing (≤50% keyword recognition in worst ear, ≤60% better ear)
  • Bypasses cochlea, direct nerve stimulation
  • Most common: Unilateral CI (sometimes bilateral or bimodal [CI+HA])
  • Best results if implanted younger

Active Middle Ear Implants (AMEIs)

  • For those who cannot use HAs/CIs or with mild-moderate HL only

Research Therapies

  • Gene/stem cell therapy (experimental)

ISSUES FOR REFERRAL

  • Sudden SNHL: otologic emergency—refer urgently
  • Audiologist: for evaluation, device fitting, rehab

ONGOING CARE

  • Monitor: Annual audiograms; check device fit/compliance
  • Education: Face-to-face communication, confirm message understood, consider speechreading classes
  • Support: Address device-related issues; encourage ongoing use

PATIENT EDUCATION

  • Hearing loss can impact mood, cognition, and social function—treatment improves quality of life.
  • Early intervention = better cognitive, emotional, and social outcomes.

ICD-10 CODES

  • H91.10: Presbycusis, unspecified ear
  • H91.13: Presbycusis, bilateral
  • H91.11: Presbycusis, right ear

CLINICAL PEARLS

  • Age-related, symmetric, high-frequency SNHL; often with tinnitus
  • Difficulty hearing in noisy conditions is classic
  • Associated with depression, social isolation, and dementia risk
  • Hearing aids, cochlear and middle ear implants can improve cognition and quality of life
  • Refer early to audiology for any suspected HL