Presbycusis
BASICS
- Definition: Age-related hearing loss (HL); gradual, progressive, bilateral, often high-frequency sensorineural HL with tinnitus.
- Presentation: Difficulty hearing in noisy environments; reduced clarity, especially for speech; “clarity” of sounds affected.
- Types:
- Central: CNS degeneration affecting perception/speech.
- Peripheral: Bilateral sensorineural HL (SNHL), symmetric.
- No cure; management is risk factor mitigation and auditory amplification (hearing aids).
EPIDEMIOLOGY
- Prevalence: Increases with age.
- 60–69 years: 27%
- 70–79 years: 55%
-
80 years: 81%
- Male > Female
ETIOLOGY AND PATHOPHYSIOLOGY
- Cochlear hair cells—critical for hearing—are lost due to noise, disease, ototoxins, and aging.
- Causes: Accumulated noise exposure, systemic disease, ototoxic drugs, genetics, oxidative damage.
- Genetic Links: GSTM1, GSTT1, NAT2*6A, GRM7, GRHL2, DFNA5, MYO6, KCNQ4; mitochondrial mutations.
- Mechanism: Hair cells don’t regenerate—damage = permanent HL.
RISK FACTORS
- Advancing age
- Noise exposure (military, industrial, leisure)
- Ototoxic drugs (aminoglycosides, cisplatin, salicylates, NSAIDs, diuretics)
- Smoking, alcohol
- Low socioeconomic status
- Family history, head trauma, otologic diseases
- Cardiovascular disease, diabetes, autoimmune/metabolic/endocrine disorders
PREVENTION
- Avoid hazardous noise exposure; use hearing protection.
- Screening: No USPSTF recommendation for routine adult screening. Tools: Hearing Handicap Inventory for the Elderly.
- RCT evidence: Screening + intervention increases hearing aid use vs. controls.
COMMONLY ASSOCIATED CONDITIONS
- Accelerated cognitive decline, dementia
- Depression, social isolation, anxiety
DIAGNOSIS
History
- Progressive, symmetric, high-frequency HL
- Speech difficulties in noisy environments
- Difficulty localizing sound; family/caregiver often notice first
- Tinnitus, but no otalgia, otorrhea, or vertigo
- If unilateral HL: consider alternate diagnosis
Physical Exam
- Whispered voice test
- Otoscopy: rule out infection, tumor, cerumen impaction, TM perforation
- Rinne/Weber: help distinguish SNHL vs. conductive HL (not for general screening)
Differential Diagnosis
- Cerumen impaction, foreign body, chronic otitis, cholesteatoma, otosclerosis, perilymph fistula, Ménière disease, acoustic neuroma (unilateral), autoimmune HL, trauma, vascular anomaly
Diagnostic Tests
- Audiometry: Symmetric high-frequency SNHL; descending slope; >2kHz affected first
- Imaging: Only if asymmetric HL (MRI for acoustic neuroma)
- Labs/other: Not routinely needed
TREATMENT
General
- No cure. Focus on risk mitigation and amplification.
Hearing Aids (HAs)
- Mainstay: OTC options for mild/moderate HL.
- Types: Analog (basic amplification), digital (programmable, background noise reduction, better adaptation).
- Average gain: ~16 dB.
- Loudness recruitment: Hypersensitivity to loud sounds
Hearing-Assistive Technologies (HATs)
- Alone or with HAs
- FM/infrared systems, induction loops, TDD, TV/telephone amplifiers, alerting devices
Aural Rehabilitation
- Patient education, training in device use, speech perception, coping strategies
Cochlear Implants (CIs)
- Indication: Poor aided hearing (≤50% keyword recognition in worst ear, ≤60% better ear)
- Bypasses cochlea, direct nerve stimulation
- Most common: Unilateral CI (sometimes bilateral or bimodal [CI+HA])
- Best results if implanted younger
Active Middle Ear Implants (AMEIs)
- For those who cannot use HAs/CIs or with mild-moderate HL only
Research Therapies
- Gene/stem cell therapy (experimental)
ISSUES FOR REFERRAL
- Sudden SNHL: otologic emergency—refer urgently
- Audiologist: for evaluation, device fitting, rehab
ONGOING CARE
- Monitor: Annual audiograms; check device fit/compliance
- Education: Face-to-face communication, confirm message understood, consider speechreading classes
- Support: Address device-related issues; encourage ongoing use
PATIENT EDUCATION
- Hearing loss can impact mood, cognition, and social function—treatment improves quality of life.
- Early intervention = better cognitive, emotional, and social outcomes.
ICD-10 CODES
- H91.10: Presbycusis, unspecified ear
- H91.13: Presbycusis, bilateral
- H91.11: Presbycusis, right ear
CLINICAL PEARLS
- Age-related, symmetric, high-frequency SNHL; often with tinnitus
- Difficulty hearing in noisy conditions is classic
- Associated with depression, social isolation, and dementia risk
- Hearing aids, cochlear and middle ear implants can improve cognition and quality of life
- Refer early to audiology for any suspected HL