Salivary Gland Calculi / Sialadenitis
BASICS
- Sialolithiasis: Obstruction of salivary gland or duct by a stone, causing painful postprandial swelling.
- Sialadenitis: Inflammation of salivary gland; can be acute (infectious) or chronic (obstructive or autoimmune).
- Common glands affected: Submandibular (80–90% of stones), parotid (acute suppurative sialadenitis), less commonly sublingual/minor glands.
EPIDEMIOLOGY
- Incidence: Peak age 30–60 years; rare in children.
- Risk factors: Debilitated, dehydrated patients; 70% single stones, 30% bilateral.
ETIOLOGY & PATHOPHYSIOLOGY
- Stone formation: Stagnation of saliva, high calcium, decreased flow (anticholinergics, dehydration, radiation).
- Composition: Calcium phosphate, hydroxyapatite, sometimes uric acid (gout).
- Infectious agents:
- Bacterial: Staph aureus, Strep viridans/pyogenes, H. influenzae, E. coli, Pseudomonas.
- Viral: Mumps, CMV, EBV, HIV, enteroviruses.
- Predisposing factors: Poor oral hygiene, trauma, gout, nephrolithiasis, Sjögren syndrome, radiation, anticholinergic use.
RISK FACTORS
- Hypovolemia, diuretics, anticholinergics, trauma, gout, head/neck radiation, poor hygiene, smoking, dehydration.
PREVENTION
- Good oral hygiene, hydration, avoid xerogenic meds.
DIAGNOSIS
History
- Acute onset swelling/pain over gland, worse with eating or anticipation.
- Dental pain, halitosis, hypersalivation, xerostomia.
- Worsening pain, erythema, fever → infection.
- In children, often mumps or idiopathic juvenile recurrent parotitis.
Physical Exam
- Palpate glands/ducts for stones (Wharton/Stensen), swelling, tenderness.
- Purulent discharge at duct orifice = acute bacterial sialadenitis.
- Assess facial nerve function (parotid).
- In children, stones usually distal duct (use US + sialendoscopy).
Differential
- Bacterial/viral parotitis, cystic fibrosis, mumps, tularemia, tumors, Sjögren, trauma.
Diagnostic Tests
- Clinical diagnosis: Sudden swelling/pain at meals, stone visible/palpable at duct.
- Imaging: US (detects 90% of stones ≥2mm), CT (higher sensitivity), MR sialography (inconclusive US), sialography/sialendoscopy (diagnostic & therapeutic), technetium scan (gland excretion).
- Labs: CBC, pus culture if discharge.
- Autoimmune workup: RF, ANA if suspected.
- Biopsy: If concern for tumor.
TREATMENT
General Measures
- Hydration, warm compresses, gland massage, sialagogues (lemon drops), oral hygiene.
- Discontinue anticholinergics.
Medication
- NSAIDs for pain.
- Antibiotics (if infection):
- Dicloxacillin or cephalexin 500 mg QID × 7–10 days
- Amox/clav or clindamycin (if no response/penicillin allergy)
- Gram negative: 3rd-gen cephalosporin, fluoroquinolone
- Anaerobic: metronidazole, clindamycin
- MRSA: vancomycin
Procedures/Surgery
- Anterior submandibular stones: Intraoral excision
- Hilum: Gland excision
- Parotid stones: Parotidectomy often needed
- Sialendoscopy: Removal of stones, stricture management (contraindicated in acute infection)
- Shockwave lithotripsy (ESWL): Large/complex stones
- Abscess: I&D if not resolving after 3–5 days antibiotics
- Stents: For chronic strictures
Additional & Alternative Therapies
- Sialagogues (tart/acidic candies)
- Chlorhexidine mouth rinse
- Complementary: Lemon drops (shown to reduce sialadenitis postop)
REFERRAL
- Dental (abscess/poor dentition)
- ENT (recurrent, refractory, surgical cases)
ONGOING CARE
- Monitor: Chronic sialadenitis (risk of recurrent acute attacks)
- Avoid: Meds causing dry mouth, sialogogues during acute attacks
- Hydration: Maintain
- Educate: Good oral hygiene, hydration
PROGNOSIS
- Most resolve in ~1 week with appropriate care.
- Chronic/autoimmune: Prolonged, recurrent.
- Surgical recurrence after stone removal: ~18%
COMPLICATIONS
- Local spread (cellulitis, Ludwig angina)
- Facial, hypoglossal, lingual nerve injury
- Dental decay (from chronic hypofunction)
ICD-10 CODES
- K11.5 Sialolithiasis
- K11.20 Sialadenitis, unspecified
- K11.21 Acute sialadenitis
CLINICAL PEARLS
- Most stones: Submandibular gland, duct.
- Mainstay: Hydration, hygiene, sialogogues, surgical removal if needed.
- Nonpharm sialagogues (tart candies, lemon drops) useful for prevention and mild cases.
- Always consider infection (purulent drainage, fever) → start antibiotics.