Attention Deficit Hyperactivity Disorder (ADHD)
Key Points ⚡
- ADHD is a neurodevelopmental disorder characterized by hyperactivity, impulsivity, and inattention.
- Symptoms must be present before age 7 and occur in multiple settings.
- Etiology involves a combination of genetic and environmental factors.
- Risk factors: prematurity, low birth weight, low paternal education, prenatal smoking, maternal depression.
- Clinical features: short attention span, rapid loss of interest, constant movement, impulsivity, poor organizational skills, acting without thinking.
- Diagnosis is clinical, using DSM-5 criteria and supported by rating scales (e.g., Conners’ rating scale, DIVA for adults).
- Primary care: watchful waiting up to 10 weeks with behavioral management and lifestyle modifications.
- Secondary care: ADHD-focused parent training; pharmacological treatment if severe (e.g., methylphenidate).
- Complications: persistence into adulthood (~60%), low educational/employment attainment, poor self-esteem, substance abuse, sleep disturbance, increased risk of criminality and road traffic accidents.
Introduction
- ADHD is defined by high activity levels and inability to concentrate.
- Prevalence worldwide ~5%, male:female ratio ~3:1, often underdiagnosed in girls.
- Symptoms must be consistent across multiple environments (home, school).
Aetiology
- Cause unknown but linked to genetic predisposition and environmental factors.
- Complex interplay between inherited and prenatal/postnatal influences.
Risk Factors
- Prematurity
- Low birth weight
- Low paternal education
- Prenatal exposure to smoking
- Maternal depression
Clinical Features
- Short attention span
- Quickly losing interest in tasks
- Constant movement/fidgeting
- Impulsive, disruptive behavior
- Poor organizational skills
- Acting without thinking
Differential Diagnosis
- Anxiety and depression: present with inattention but include worry, low mood.
- Autism spectrum disorder: poor impulse control, social communication deficits.
- Childhood trauma/PTSD: avoidance, anxiety, behavioral changes.
- Other: conduct disorder, learning disabilities, epilepsy.
Diagnosis
- Specialist clinical diagnosis using DSM-5 criteria:
- Children ≤16 years: ≥6 symptoms of inattention and/or hyperactivity-impulsivity.
- Adults ≥17 years: ≥5 symptoms.
- Symptoms present for ≥6 months in ≥2 settings.
- Tools: Strengths and Difficulties Questionnaire, Conners’ rating scale, DIVA questionnaire for adults.
- Important to exclude situational/environmental causes.
DSM-5 Diagnostic Criteria Summary
| Inattention Symptoms | Hyperactivity/Impulsivity Symptoms |
|---|---|
| Careless mistakes | Fidgeting, difficulty staying seated |
| Difficulty sustaining attention | Running/climbing in inappropriate settings |
| Often distracted | Inability to play quietly |
| Often forgetful | Talking excessively |
| Losing things | Interrupting or intruding on others |
| Avoids tasks needing sustained effort | Blurting out answers |
Management
Primary Care
- Watchful waiting up to 10 weeks.
- Promote healthy diet, regular exercise.
- Behavioral management: reward charts, positive redirection, task breakdown (1-2-3-reward).
- Referral to CAMHS or specialist if symptoms persist or severe.
Secondary Care
- ADHD-focused parent training programs.
- Pharmacotherapy (if needed): methylphenidate (CNS stimulant) with monitoring of growth, heart rate, blood pressure every 6 months.
Complications
- Symptoms persist into adulthood in ~60%.
- Associated with:
- Lower educational and employment attainment.
- Poor self-esteem.
- Criminal behavior.
- Relationship difficulties.
- Sleep disturbances.
- Substance misuse.
- Increased risk of road traffic accidents.
- Self-harm.
References
- NICE CKS. Attention Deficit Hyperactivity Disorder.
- Larsson H et al., 2014. Heritability of ADHD.
- Sciberras E et al., 2017. Prenatal risk factors.
- Roberts W et al., 2014. Impulsivity and substance use.
- BNF. Methylphenidate hydrochloride, 2021.
Related Notes
- Autism Spectrum Disorder (ASD)
- Childhood Immunisations
- Cerebral Palsy
- Biliary Atresia
- Bronchiolitis